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CJHR 2019, 4(4): 86-89 Back to browse issues page
Association of Diabetes Mellitus Type 2 and Alzheimer's Disease
Sasan Andalib 1, Amirreza Ghayeghran2, Yaser Moadabi2, Kamran Asadi3, Maryam Mohammadpour2, Samaneh Ghorbani-Shirkouhi4
1- Neuroscience Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran , andalib@gums.ac.ir
2- Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
3- Orthopaedic Research Center, Department of Orthopaedic Surgery, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
4- Neuroscience Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
Abstract:   (321 Views)
Background: Insulin serves an important role in brain metabolism, and insulin resistance and subsequent diabetes mellitus type 2 (DM2) can give rise to dysfunction of brain metabolism. This study aimed to test the hypothesis of association of late onset Alzheimer's disease (AD) with DM2 in an Iranian population.
Methods: In this case-control study, 243 subjects including 81 patients with late onset AD and 162 healthy controls were recruited. The frequency of DM were compared in AD patients with non-AD counterparts.
Results: The prevalence of diabetes in AD and control patients was 27% and 9%, respectively. (OR = 3.94, 95% confidence interval: 1.89-8.22). After adjustment for age and gender, there was a significant association between DM2 and AD (OR = 3.7, 95% confidence interval: 1.73-8.00).
Conclusion: The evidence from the present study suggested that DM2 was associated with AD in an Iranian population. Further longitudinal studies are warranted to confirm this finding.
Keywords: Alzheimer's disease, Brain metabolism, Diabetes mellitus type 2, Insulin resistance
Full-Text [PDF 528 kb]   (72 Downloads)    
Article Type: Original Contributions | Subject: Epidemiology
Received: 2019/07/27 | Accepted: 2019/09/18 | Published: 2019/10/1
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Andalib S, Ghayeghran A, Moadabi Y, Asadi K, Mohammadpour M, Ghorbani-Shirkouhi S. Association of Diabetes Mellitus Type 2 and Alzheimer's Disease. CJHR. 2019; 4 (4) :86-89
URL: http://cjhr.gums.ac.ir/article-1-135-en.html

Volume 4, Issue 4 (10-2019) Back to browse issues page
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