AU - Andalib, Sasan AU - Ghayeghran, Amirreza AU - Moadabi, Yaser AU - Asadi, Kamran AU - Mohammadpour, Maryam AU - Ghorbani-Shirkouhi, Samaneh TI - Association of Diabetes Mellitus Type 2 and Alzheimer's Disease PT - JOURNAL ARTICLE TA - gums-cjhr JN - gums-cjhr VO - 4 VI - 4 IP - 4 4099 - http://cjhr.gums.ac.ir/article-1-135-en.html 4100 - http://cjhr.gums.ac.ir/article-1-135-en.pdf SO - gums-cjhr 4 ABĀ  - Background: Insulin serves an important role in brain metabolism, and insulin resistance and subsequent diabetes mellitus type 2 (DM2) can give rise to dysfunction of brain metabolism. This study aimed to test the hypothesis of association of late onset Alzheimer's disease (AD) with DM2 in an Iranian population. Methods: In this case-control study, 243 subjects including 81 patients with late onset AD and 162 healthy controls were recruited. The frequency of DM were compared in AD patients with non-AD counterparts. Results: The prevalence of diabetes in AD and control patients was 27% and 9%, respectively. (OR = 3.94, 95% confidence interval: 1.89-8.22). After adjustment for age and gender, there was a significant association between DM2 and AD (OR = 3.7, 95% confidence interval: 1.73-8.00). Conclusion: The evidence from the present study suggested that DM2 was associated with AD in an Iranian population. Further longitudinal studies are warranted to confirm this finding. CP - IRAN IN - LG - eng PB - gums-cjhr PG - 86 PT - Original Contributions YR - 2019