Volume 10, Issue 4 (10-2025)
CJHR 2025, 10(4): 0-0 |
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Jedinia A, Joukar F, Maroufizadeh S, Asgharnezhad M, Pourseyedian A, Mansour-Ghanaei F et al . Link Between Helicobacter pylori Infection and Colorectal Polyps: Implications for Screening in Northern Iran. CJHR 2025; 10 (4)
URL: http://cjhr.gums.ac.ir/article-1-439-en.html
URL: http://cjhr.gums.ac.ir/article-1-439-en.html
Alieh Jedinia1 
, Farahnaz Joukar2 , Saman Maroufizadeh3 , Mehrnaz Asgharnezhad2 , Abed Pourseyedian4 , Fariborz Mansour-Ghanaei1 , Kourosh Mojtahedi *5
, Farahnaz Joukar2 , Saman Maroufizadeh3 , Mehrnaz Asgharnezhad2 , Abed Pourseyedian4 , Fariborz Mansour-Ghanaei1 , Kourosh Mojtahedi *5
1- Department of Internal Medicine, School of Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran. 2Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
2- Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
3- Department of Biostatistics, School of Health, Guilan University of Medical Sciences, Rasht, Iran.
4- Department of Internal Medicine, School of Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran.
5- Department of Internal Medicine, School of Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran. 2Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. ,K.moj2013@gmail.com
2- Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
3- Department of Biostatistics, School of Health, Guilan University of Medical Sciences, Rasht, Iran.
4- Department of Internal Medicine, School of Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran.
5- Department of Internal Medicine, School of Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran. 2Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. ,
Abstract: (76 Views)
Background: Helicobacter pylori (H. pylori) is a common gastrointestinal pathogen implicated in gastric malignancies, and emerging evidence suggests a potential link to colorectal neoplasia. Objectives: This study was aimed to investigate the relationship between H. pylori infection and colorectal polyps in a Middle Eastern population with high background prevalence of both conditions.
Materials & Methods: In this hospital-based cross-sectional analytical study, 382 adults undergoing both upper endoscopy and colonoscopy at Razi Hospital in Rasht, Iran, were enrolled over a one-year period. H. pylori infection was detected via histopathological examination of gastric biopsies. Colorectal polyps were identified during colonoscopy and confirmed by histological evaluation. Demographic, clinical, and lifestyle data were collected. Logistic regression analyses were performed to assess the association between H. pylori infection and colorectal polyps, adjusting for age, sex, and other confounders.
Results: The mean age of participants was 56.93 ± 13.51years with aged 18 years and older. The overall prevalence of H. pylori infection and colorectal polyps was 48.4% and 33.0%, respectively. No significant association was observed between H. pylori infection and colorectal polyps in unadjusted (OR=1.10; 95% CI: 0.72–1.68; P=0.667) or adjusted models (adjusted OR=1.19; 95% CI: 0.76–1.87; P=0.435). Polyp prevalence increased significantly with age (P for trend = 0.049) but did not differ by sex or H. pylori status.
Conclusion: This study found no significant association between H. pylori infection and colorectal polyps. These results underscore the need for further prospective and mechanistic research across diverse populations to clarify this relationship.
Materials & Methods: In this hospital-based cross-sectional analytical study, 382 adults undergoing both upper endoscopy and colonoscopy at Razi Hospital in Rasht, Iran, were enrolled over a one-year period. H. pylori infection was detected via histopathological examination of gastric biopsies. Colorectal polyps were identified during colonoscopy and confirmed by histological evaluation. Demographic, clinical, and lifestyle data were collected. Logistic regression analyses were performed to assess the association between H. pylori infection and colorectal polyps, adjusting for age, sex, and other confounders.
Results: The mean age of participants was 56.93 ± 13.51years with aged 18 years and older. The overall prevalence of H. pylori infection and colorectal polyps was 48.4% and 33.0%, respectively. No significant association was observed between H. pylori infection and colorectal polyps in unadjusted (OR=1.10; 95% CI: 0.72–1.68; P=0.667) or adjusted models (adjusted OR=1.19; 95% CI: 0.76–1.87; P=0.435). Polyp prevalence increased significantly with age (P for trend = 0.049) but did not differ by sex or H. pylori status.
Conclusion: This study found no significant association between H. pylori infection and colorectal polyps. These results underscore the need for further prospective and mechanistic research across diverse populations to clarify this relationship.
Article Type: Original Contributions |
Subject:
Health Management
Received: 2025/07/10 | Accepted: 2025/08/7 | Published: 2025/10/18
Received: 2025/07/10 | Accepted: 2025/08/7 | Published: 2025/10/18
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