Volume 4, Issue 4 (10-2019)
CJHR 2019, 4(4): 86-89 |
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Andalib S, Ghayeghran A, Moadabi Y, Asadi K, Mohammadpour M, Ghorbani-Shirkouhi S. Association of Diabetes Mellitus Type 2 and Alzheimer's Disease. CJHR 2019; 4 (4) :86-89
URL: http://cjhr.gums.ac.ir/article-1-135-en.html
URL: http://cjhr.gums.ac.ir/article-1-135-en.html
Sasan Andalib * 
1, Amirreza Ghayeghran2 , Yaser Moadabi2 , Kamran Asadi3 , Maryam Mohammadpour2 , Samaneh Ghorbani-Shirkouhi4
1, Amirreza Ghayeghran2 , Yaser Moadabi2 , Kamran Asadi3 , Maryam Mohammadpour2 , Samaneh Ghorbani-Shirkouhi4
1- Neuroscience Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran , andalib@gums.ac.ir
2- Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
3- Orthopaedic Research Center, Department of Orthopaedic Surgery, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
4- Neuroscience Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
2- Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
3- Orthopaedic Research Center, Department of Orthopaedic Surgery, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
4- Neuroscience Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
Abstract: (2018 Views)
Background: Insulin serves an important role in brain metabolism, and insulin resistance and subsequent diabetes mellitus type 2 (DM2) can give rise to dysfunction of brain metabolism. This study aimed to test the hypothesis of association of late onset Alzheimer's disease (AD) with DM2 in an Iranian population.
Methods: In this case-control study, 243 subjects including 81 patients with late onset AD and 162 healthy controls were recruited. The frequency of DM were compared in AD patients with non-AD counterparts.
Results: The prevalence of diabetes in AD and control patients was 27% and 9%, respectively. (OR = 3.94, 95% confidence interval: 1.89-8.22). After adjustment for age and gender, there was a significant association between DM2 and AD (OR = 3.7, 95% confidence interval: 1.73-8.00).
Conclusion: The evidence from the present study suggested that DM2 was associated with AD in an Iranian population. Further longitudinal studies are warranted to confirm this finding.
Methods: In this case-control study, 243 subjects including 81 patients with late onset AD and 162 healthy controls were recruited. The frequency of DM were compared in AD patients with non-AD counterparts.
Results: The prevalence of diabetes in AD and control patients was 27% and 9%, respectively. (OR = 3.94, 95% confidence interval: 1.89-8.22). After adjustment for age and gender, there was a significant association between DM2 and AD (OR = 3.7, 95% confidence interval: 1.73-8.00).
Conclusion: The evidence from the present study suggested that DM2 was associated with AD in an Iranian population. Further longitudinal studies are warranted to confirm this finding.
Article Type: Original Contributions |
Subject:
Epidemiology
Received: 2019/07/27 | Accepted: 2019/09/18 | Published: 2019/10/1
Received: 2019/07/27 | Accepted: 2019/09/18 | Published: 2019/10/1
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